Computational Structural Biology Group
Principal Investigator
Dr. Bajarang Kumbhar
M.Sc. Ph.D. (Biochemistry)
Post-Doc: Indian Institute of Technology Bombay (2014–2017)
PhD: Shivaji University, Kolhapur
Research Area: Computational Structural Biology, Drug design, and discovery, Chimeric Antigen Receptor-T design
Purva is involved in the computational design of chimeric antigen receptor (CAR) structures and the analysis of their interactions with cancer-specific B cell antigens using both in-silico and in-vitro approaches. Additionally, she is exploring the signal transduction mechanisms that govern CAR-T cell activation and function.
Pruthanka is working on computational drug discovery of anti-mitotic agents targeting the drug resistant tubulin isotypes. She is employing the structure based drug discovery, machine learning and molecular dynamics simulation to identify the potential candidates and further validated using experimental approach.
Pratiksha is working on the structure-guided design of a chimeric antigen receptor (CAR) targeting the CD19 antigen. While CD19 is a well-established and FDA-approved CAR target, certain mutations can lead to reduced antigen affinity. Her work aims to optimize CAR-scFv constructs to enhance binding efficiency and develop better CAR designs.
Asma is working as a project staff on ICMR funded project and she is working on tubulin isolation, purification, tubulin-drug interaction, tubulin isotype specific purification and SPR study.