Assistant Professor, Biological Sciences
Specialization: Microbiology, Pharmacology, Cell Biology
B.Sc., M.Sc., PGDCR, Ph.D.
Areas of Specialisation
Microbiology, Cell Biology, Immunology, Pharmacology
Academic Experience
Dr. Brijesh has been working with School of Science from June 2011. Previously, he has worked at the Foundation for Medical Research (FMR), Mumbai, as a Post-Doctoral Fellow. His responsibilities were to format initiatives and design processes towards down-streaming the potential of the guava leaf extract as an anti-diarrhoeal into a standardized product.
Areas of Research
1. Currently, his work involves developing nano-drug delivery systems such as solid lipid nanoparticles (SLN), niosomes, nano-structures lipid carries (NLC) and nanoemulsions for delivery of combination of drugs used in treatment of rheumatoid arthritis and psoriasis. The focus, on one hand, has been on synthesising SLNs and encapsulation of anti-rheumatic drugs using a Quality by Design (QbD) approach for oral delivery. On the other hand, niosomes, NLCs and nanomulsions are being explored for their potential for topical delivery of anti-rheumatic and anti-psoriatic drugs
2. Previously, his work also involved evaluation of the mechanism of action of medicinal plants with anxiolytic and anti-depressant activities using animal models and identifying the molecule for observed activities using molecular docking studies.
Current Academic and non-Academic Activities
1. Teaching students of courses such as 5-Year Integrated M.Sc. in Biomedical Science, M.Sc./Integrated M.Sc.-Ph.D. in Biological Sciences.
2. Guiding research work of Ph. D. students
·Completed: 3
o Dr. Ritu Mishra
o Dr. Sameera Kargutkar
o Dr. Miloni Thakkar
·Ongoing: 6
o Ms. Jeanette Martins
o Ms. Swati Sahoo
o Ms. Yashika Mirchandani
o Ms. Amruta Parmar
o Ms. Ruchita Joshi
o Ms. Hera Khan
3. Editor at the Biomedical Research Journal (BRJ).
4. Program Chair-person of the "5-Year Integrated M.Sc. in Biomedical Science” program.
5. Member Secretary:
·BOS of the "5-Year Integrated M.Sc. in Biomedical Science” program.
·SVKM’s Institutional Ethics Committee (IEC)
6. In-charge of the Students’ Disciplinary Committee, SDSOS Library.
Membership / Fellowship of Professional Societies
Life member of Mumbai Immunology Group
Life member of Indian Science Congress Association
Publications at SDSOS:
1. Shaoo S, Kharkar PS, Sahu NU, Brijesh S. Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain. Phytotherapy Research. 2020. https://doi.org/10.1002/ptr.6900 (IF: 4.087)
2. Sahoo S, Brijesh S. Anxiolytic activity of Coriandrum sativum seeds aqueous extract on chronic restraint stressed mice and effect on brain neurotransmitters. Journal of Functional Foods. 2020. 68: 103884. (IF: 3.701)
3. Martin J, Brijesh S. Anti-depressant activity of Erythrina variegata bark extract and regulation of monoamine oxidase activities in mice. Journal of Ethnopharmacology. 2020. 248: 112280. (IF: 3.690)
4. Sahoo S, Brijesh S. Pharmacogenomic assessment of herbal drugs in affective disorders. Biomedicine and Pharmacotherapy. 2019. 109: 1148–1162. (IF: 4.545)
5. Parmar A, Brijesh S. Niosomes as Transdermal Drug Delivery System. Biomedical Research Journal. 2018. 5(2): 54–63.
6. Martins J, Brijesh S. Phytochemistry and pharmacology of anti-depressant medicinal plants: A review. Biomedicine & Pharmacotherapy. 2018. 104: 343–365. (IF: 4.545)
7. Thakkar M, Brijesh S. Stability-indicating HPLC method for primaquine diphosphate: An application to niosomal formulation. Biomedical Research Journal. 2018. 5(1), 39–51.
8. Thakkar M, Brijesh S. Physicochemical investigation and in vivo activity of anti-malarial drugs co-loaded in Tween 80 niosomes. Journal of Liposome Research. 2018. 28(4): 315–321. (IF: 2.455)
9. Kargutkar S, Brijesh S. Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus. Inflammopharmacology. 2017. 26(2): 469–477. (IF: 3.238)
10. Thakkar M, Brijesh S. Opportunities and challenges for niosomes as drug delivery systems. Current Drug Delivery 2016. 13(8): 1275–1289. (IF: 1.582)
11. Kargutkar S, Brijesh S. Anti-rheumatic activity of Ananas comosus fruit peel extract in a complete Freund’s adjuvant rat model. Pharmaceutical Biology. 2016; 54 (11), 2616–2622. (IF: 2.971)
12. Thakkar M, Brijesh S. Combating malaria with nanotechnology-based targeted and combinatorial drug delivery strategies. Drug Delivery and Translational Research. 2016. 6 (4): 414–425. (IF: 2.664)
13. Mishra R, Pandit K, Bhagwat AM, Brijesh S. Antihyperlipidemic activity of alcoholic extracts of Trichosanthes anguina in Triton WR 1339 induced hyperlipidemic rats. International Journal of Pharmaceutical Sciences and Research. 2014. 5(10): 4269–4274.
14. Pandit K, Mishra R, Brijesh S, Bhagwat A, Bhatt P. Lipid lowering activity of Feronia limonia leaf in Triton WR-1339 (Tyloxapol) induced hyperlipidemic rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2014. 6(8): 156–158.
