connect with us
For further information please fill the details below:
Skip to main content

Stem Cell Research at School of Science funded by Department of Science & Technology (Govt of India) under NanoMission Scheme

Dr. Aparna Khanna, Dean, School of Science has received a grant from DST Nanomission for the project entitled “Synthesis and Characterization of novel nanoparticles and study of their interactions with stem cells”. The grant of Rs 45 lakhs was received in January 2013 for a period of three years. The Co-Principal Investigator of the project is Dr. Dhirendra Bahadur, Department of Metallurgical Engineering and Material Science, Indian Institute of Technology Bombay, Mumbai.

The project deals with the synthesis, characterisation of biocompatible human serum albumin coated iron oxide nanoparticles (HSA-IONPs) and their effect on human umbilical cord derived mesenchymal stem cells (hUC-MSCs). Detailed analysis showed that HSA-IONPs were found to be colloidally stable and did not show any toxicity to the stem cells. Further, the engulfment of the HSA-IONPs did not show any detrimental effect on the differentiation potential of the stem cells into adipocytes, osteocytes and chondrocytes, thereby confirming that the inherent properties of stem cells were maintained. The outcome of the study is that the HSA-IONPs, proves to be a promising alternative for future in vivo studies

A graphical representation of the work is represented below:

Publications:

  1. Sanganeria P, Sachar S, Chandra S, Bahadur D, Ray P, Khanna A. (2015). Cellular internalization and detailed toxicity analysis of protein-immobilized iron oxide nanoparticles. J Biomed Mater Res B Appl Biomater. 2015 Jan;103(1):125-34.
  2. Sanganeria P, Chandra S, Bahadur D, Khanna A. (2015).Effect of HSA coated iron oxide labeling on human umbilical cord derived mesenchymal stem cells. Nanotechnology. 2015 Mar 27;26(12):125103

AMSAB 2019 conference

Connect With Us x