DR. PURVI BHATT

Academic Background

B.Sc: Microbiology, Mumbai University, Mumbai, 1995

MSc: Microbiology, Mumbai University, Mumbai, 1997

Ph.D: Biochemistry, ICMR-NIRRH, Mumbai University, Mumbai, 2003

Professional Experience

• Associate Professor: SDSOS NMIMS Deemed to be University, 2017-to date
• Assistant Professor: SDSOS NMIMS Deemed-to be University, 2007-2016
• Lecturer: Thadomal Shahani Engineering College, Mumbai, May September 2007
• Post Doctoral Fellow: New York University (NYU) Medical Centre, NY, USA, 2003 to 2006

Research Interest

Our lab is currently working in the area of cancer biology. Our research lies at the intersection of cancer biology, cellular senescence, and molecular therapeutics. The work extensively investigates therapy-induced senescence (TIS) in cancer that leads to cancer relapse and metastasis in breast cancer with a focus on identifying biomarkers of TIS, understanding the epigenetic mechanisms involved, and screening compounds with senotherapeutic potential.  We are using a multi-omics approach in an in vitro cell culture model to identify the biomarkers of senescence that will help us address the fundamental questions in cancer biology, relapse, and metastasis.

Recent Publications:

• Mitesh Joshi, Purvi Bhatt. Ameliorated In vitro anti-cancer efficacy of Methotrexate loaded Zinc oxide nanoparticles in breast cancer cell lines MCF-7 & MDA-MB-231 and its acute toxicity study. Nanotechnology, 35, 33 (2024). DOI https://iopscience.iop.org/article/10.1088/1361-6528/ad4b24/meta. (IF- 2.85) Q2.
• Mitesh Joshi, Purvi Bhatt. Deciphering the anticancer activity of biocompatible zinc oxide nanoparticles loaded with methotrexate on breast cancer cells. Bull Mater Sci 46, 192 (2023). https://doi.org/10.1007/s12034-023-03044-9 (Impact factor- 2.23) Q2.
• Saniya Laheri, Nancy Ashary, Purvi Bhatt, Deepak Modi (2018). Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion. Journal of Assisted Reproduction and Genetics (JARG). Aug;35(8):1419-1429. Epub 2018 Jun 30. https://doi.org/10.1007/s10815-018-1231-4  (Impact factor- 2.45) Q1.
• Maneka Hoonjan, Geetanjali Sachdeva,  Sudeshna Chandra,  Prashant Suresh Kharkar,  Niteshkumar Sahu, Purvi J Bhatt (May 2018). Investigation of HSA as a biocompatible coating material for Arsenic Trioxide Nanoparticles.  2018, 10(17), 8031 - 8041 https://doi.org/10.1039/C7NR09503A  (Impact factor- 65.15) Q1.
• Saniya A Laheri, Deepak Modi, Purvi Bhatt (Mar 2017). Extra-oviductal expression of Oviductal glycoprotein 1 in the mouse: Detection in testis, epididymis and ovary. Journal of Biosciences (J Biosci.), Mar; 42(1):69-80. https://doi.org/10.1007/s12038-016-9657-2 (Impact factor-1.63) Q2.

Teaching

• Recombinant DNA Technology
• Omics
• Research and Publication Ethics
• Drug Discovery and Clinical Research

Awards/Honor

• VC Nominated RRC Member of Biotechnology at Mumbai University (till 2027)
• Best Faculty Award, AY 2017-18
• Recipient of CSIR-Senior Research Fellowship (SRF) (Aug 2001- May 2003)
• Recipient of Lady Tata Memorial Trust (LTMT) Junior and Senior Research Fellowship (JRF & SRF) (Jul 1998- Jul 2001)
• Recipient of ICMR-Junior Research Fellowship (Jan 1998- Jun 1998)