Dr. Brijesh Sukumaran

Assistant Professor, Biological Sciences

Specialization: Microbiology, Pharmacology, Cell Biology
B.Sc., M.Sc., PGDCR, Ph.D.

Areas of Specialisation

Microbiology, Cell Biology, Immunology, Pharmacology

Academic Experience

Dr. Brijesh has been working with School of Science from June 2011. Previously, he has worked at the Foundation for Medical Research (FMR), Mumbai, as a Post-Doctoral Fellow. His responsibilities were to format initiatives and design processes towards down-streaming the potential of the guava leaf extract as an anti-diarrhoeal into a standardized product.

Areas of Research

1. Currently his work involves evaluating the mechanism of action of medicinal plants with anxiolytic and anti-depressant activities using animal models and gene expression studies and identifying the molecule for observed activities using molecular docking studies.

2. Another aspect of his current research activities is to evaluate nano-drug delivery systems such as solid lipid nanoparticles (SLN), niosomes, nano-structures lipid carries (NLC) and nanoemulsions for delivery of combination of drugs used in treatment of rheumatoid arthritis and psoriasis. The focus, on one hand, has been on synthesising SLNs and encapsulation of anti-rheumatic drugs using a Quality by Design (QbD) approach for oral delivery. On the other hand, niosomes NLCs and nanomulsions are being explored for their potential for topical delivery of anti-rheumatic and anti-psoriatic drugs

Current Academic and non-Academic Activities

- Teaching Biochemistry, Bioanalytical Chemistry, Biostatistics, Cell Biology, Immunology, Microbiology, and Pharmacology to U.G., P.G. and Ph.D. students of the Biomedical Science and Biological Sciences courses.
- Guiding research work of Ph. D. students. Completed: 5; Ongoing: 3
- Associate Editor at the Biomedical Research Journal (BRJ).
- Program Chair-person of the "5-Year Integrated M.Sc. in Biomedical Science” program.
- Member Secretary: 1) BOS of the "5-Year Integrated M.Sc. in Biomedical Science” program. 2) SVKM’s Institutional Ethics Committee (IEC)
- In-charge of the Students’ Disciplinary Committee, SDSOS Student's Council.

Membership / Fellowship of Professional Societies

Life member of Mumbai Immunology Group

Life member of Indian Science Congress Association

Publications

In Journals

1. Mirchandani Y, Patravale VB, Brijesh S. Solid lipid nanoparticles for hydrophilic drugs. Journal of Controlled Release. 2021. 335: 457–464. Impact Factor: 9.776
2. Sahoo S, Kharkar PS, Sahu NU, Brijesh S. Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain. Phytotherapy Research. 2021. 35(3): 1399–1415. Impact Factor: 4.087
3. Sahoo S, Brijesh S. Anxiolytic activity of Coriandrum sativum seeds aqueous extract on chronic restraint stressed mice and effect on brain neurotransmitters. Journal of Functional Foods. 2020. 68: 103884. Impact Factor: 3.701
4. Martins J, Brijesh S. Anti-depressant activity of Erythrina variegata bark extract and regulation of monoamine oxidase activities in mice. Journal of Ethnopharmacology. 2019. 248: 112280. Impact Factor: 3.690
5. Sahoo S, Brijesh S. Pharmacogenomic assessment of herbal drugs in affective disorders. Biomedicine and Pharmacotherapy. 2019. 109: 1148–1162. Impact Factor: 4.545
6. Parmar A, Brijesh S. Niosomes as transdermal drug delivery system. Biomedical Research Journal. 2018. 5(2): 54–63.
7. Martins J, Brijesh S. Phytochemistry and pharmacology of anti-depressant medicinal plants: A review. Biomedicine and Pharmacotherapy. 2018. 104: 343–365. Impact Factor: 4.545
8. Thakkar M, Brijesh S. Stability-indicating HPLC method for primaquine diphosphate: An application to niosomal formulation. Biomedical Research Journal. 2018. 5(1): 39–51.
9. Thakkar M, Brijesh S. Physicochemical investigation and in vivo activity of anti-malarial drugs co-loaded in Tween 80 niosomes. Journal of Liposome Research. 2018. 28(4): 315–321. Impact Factor: 2.455
10. Kargutkar S, Brijesh S. Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus. Inflammopharmacology. 2017. 26(2): 469–477. Impact Factor: 3.238
11. Thakkar M, Brijesh S. Opportunities and challenges for niosomes as multiple drug delivery systems for combination therapy. Current Drug Delivery. 2016;13(8):1275–1289. Impact Factor: 1.582
12. Thakkar M, Brijesh S. Combating malaria with nanotechnology-based targeted and combinatorial drug delivery strategies. Drug Delivery and Translational Research. 2016;6(4):414–425. Impact Factor: 2.664
13. Kargutkar S, Brijesh S. Anti-rheumatic activity of Ananas comosus fruit peel extract in complete Freund’s adjuvant rat model. Pharmaceutical Biology. 2016;54(11): 2616–2622. Impact Factor: 2.971
14. Mishra R, Pandit K, Bhagwat AM, Brijesh S. Antihyperlipidemic activity of alcoholic extracts of Trichosanthes anguina in Triton WR 1339 induced hyperlipidemic rats. International Journal of Pharmaceutical Sciences and Research. 2014;5(10): 4269–4274.
15. Birdi TJ, Brijesh S, Daswani PG. Bactericidal effect of selected antidiarrhoeal medicinal plants on intracellular heat-stable enterotoxin-producing Escherichia coli. Indian Journal of Pharmaceutical Sciences. 2014. 76(3): 229–235. Impact Factor: 0.721
16. Pandit K, Mishra R, Brijesh S, Bhagwat A, Bhatt P. Lipid lowering activity of Feronia limonia leaf in Triton WR-1339 (Tyloxapol) induced hyperlipidemic rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2014. 6(8): 156–158.
17. Brijesh S, Tetali P, Antia N, Birdi T. Study on effect of anti-diarrhoeal medicinal plants on enteropathogenic Escherichia coli induced interleukin-8 secretion by intestinal epithelial cells. Alternative Medicine Studies. 2011. 1:e16: 64–69.
18. Daswani PG, Ghadge A, Brijesh S, Birdi TJ. Preparation of decoction of medicinal plants – A self-help measure. Journal of Alternative and Complementary Medicine. 2011. 17(12): 1099–1100. Impact Factor: 2.256
19. Birdi TJ, Daswani PG, Brijesh S, Tetali P. In vitro antigiardial and antirotaviral activity of Psidium guajava L. leaves. Indian Journal of Pharmacology. 2011. 43(5): 616–617. Impact Factor: 0.888
20. Daswani PG, Brijesh S, Tetali P, Birdi TJ. Studies on the activity of Cyperus rotundus Linn. tubers against infectious diarrhea. Indian Journal Pharmacology. 2011. 43(3): 340–344. Impact Factor: 0.888
21. Birdi T, Daswani P, Brijesh S, Tatali P, Antia N, Natu A. Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea. BiomedCentral Complementary and Alternative Medicine. 2010. 10: 33. Impact Factor: 2.833
22. Daswani PG, Brijesh S, Tetali P, Antia NH, Birdi TJ. Studies on Antidiarrhoeal Activity of Zingiber officinale (Rosc.). Current Science. 2010. 98(2): 222–229. Impact Factor: 0.883
23. Brijesh S, Daswani P, Tetali P, Antia N, Birdi T. Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage. BiomedCentral Complementary and Alternative Medicine. 2009. 9: 47. Impact Factor: 2.833
24. Birdi TJ, Brijesh S, Daswani PG. 2006. Approaches towards the preclinical testing and standardization of medicinal plants. Report of the South Asian Regional Conference on "Traditional Medicine and Right to Health for All” held at Bangalore. 13th – 15th December 2006. p. 103–119.
25. Brijesh S, Daswani PG, Birdi TJ. 2006. Approaches to standardization of medicinal plant preparations. Proceedings of the workshop entitled "Approaches towards Evaluation of Medicinal Plants prior to Clinical Trials.” Organized at YASHADA, Pune on 8th November 2006. p. 101–114.
26. Daswani PG, Brijesh S, Birdi TJ. 2006. Preclinical testing of Medicinal plants: advantages and approaches. Proceedings of the workshop entitled "Approaches towards Evaluation of Medicinal Plants prior to Clinical Trials.” Organized at YASHADA, Pune on 8th November 2006. p. 61–76.
27. Brijesh S, Daswani PG, Tetali P, Rojatkar SR, Antia NH, Birdi TJ. Studies on Pongamia pinnata (L.) Pierre leaves: Understanding the mechanism(s) of action in infectious diarrhea. Journal of Zhejiang University SCIENCE B. 2006. 7: 665–674. Impact Factor: 2.082
28. Brijesh S, Daswani PG, Tetali P, Antia NH. Birdi TJ. Studies on Dalbergia sissoo (Roxb.) leaves: Possible mechanism(s) of action in infectious diarrhoea. Indian Journal of Pharmacology. 2006. 38: 120–124. Impact Factor: 0.888

Official Email Id

brijesh.sukumaran@nmims.edu