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Home > Faculty-and-research > Research-areas-and-groups >

RESEARCH: AREAS & GROUPS

The NMIMS Sunandan Divatia School of Science is strongly driven by highly qualified scientific talent pool. The main focus of our R & D activities has been to conduct applied research at the interface of Chemistry and the Biosciences on current problems of national importance.

Various research oriented projects in the area of Biological Sciences and Chemical Sciences that have been initiated at Sunandan Divatia School of Science have been highlighted below:

 

 

Stem Cell Research

Overview

Osteochondral defects (OCD) in knee joint remains to be the most challenging clinical problem for orthopedic surgeons with maximum disability in young athletes and old age people. Owing to the limited healing capacity of articular cartilage, it is difficult to treat OCD, leading to disabling pain and early osteoarthritis in a longer run. Thus, timely surgical involvement is required to restore the normal functioning of the knee joint and prevent it from further damage. Commonly used treatments for OCD are less satisfactory, don't restore cartilage function and may even lead to formation of fibrocartilage over hyaline cartilage. Bone marrow mesenchymal stem cells (BMSCs) appear to be an attractive alternate cellular source due to its immunotolerant and immunomodulatory properties. Reports have shown easy proliferation and differentiation of BMSCs into bone and cartilage with properties similar to true hyaline cartilage. In spite of this fact, there is need of a reliable, clinically applicable cell tracker for deciphering the homing and distribution of stem cells post transplantation. Thus, the rationale of this study was to develop biocompatible magnetic iron oxide nanoparticles (IONPs) that can be used as a cell labeling and tracking agent for bone marrow derived mesenchymal stem cells (BMSCs). Labeled BMSCs were investigated for detailed toxicity (in vitro and in vivo) analysis followed by its administration in an osteochondral defect created in femur bone of Wistar rats. Regeneration of bone and cartilage was evaluated by magnetic resonance imaging (MRI), histopathological analysis and Immunohistochemistry (IHC). We believe that the current project will serve dual purpose for articular cartilage regeneration using BMSCs and its subsequent imaging using magnetic nanoparticles via MRI.

 

 

Faculty Involved:

Dr. Aparna Khanna

Dr. Sudeshna Chandra

Selected Publications:

  • Shelat R, Bhatt LK, Khanna A and Chandra S. A comprehensive toxicity evaluation of novel amino acid modified magnetic ferrofluids for magnetic resonance imaging. 2019. Amino Acid
  • Shelat R, Bhatt LK, Chandra S and Khanna A. Detailed toxicity evaluation of β-cyclodextrin coated iron oxide nanoparticles for biomedical applications. International Journal of Biological Macromolecules. 2018. 110, 357-365
  • Raut A, Khanna A. High-throughput sequencing to identify microRNA signatures during hepatic differentiation of human umbilical cord Wharton's jelly-derived mesenchymal stem cells. 2016. Hepatology Research
  • Chitrangi S, Nair P, Khanna A. 3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism. 2016. Toxicology in Vitro
           
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