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Biomedical Research Journal

Volume 2, Issue 2, October 2015, Pages 220–232

Review

Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis

Garima Pandey1, Abhay Kumar Pandey2*, S. S. Pandey1, B. L. Pandey3

1Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

2Department of Physiology, All India Institute of Medical Sciences, Bhopal, India

3Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Abstract:

Psoriasis is a common autoimmune inflammatory disease wherein pathogenesis is advanced by fundamental genetic predisposition/s in concert with environmental triggers. Inflammation in psoriasis may represent efforts of innate immune system to target pathogens for restoring immune homeostasis. Aberrant microbiota may resist elimination efforts by shear advantage of several fold gene pool as compared to the host. The microbes deregulate gene expression by the molecular insults targeting host immune system. Role of microbiota in autoimmunity dictates establishment of microbiome homeostasis and suppress host immune response; as a treatment approach. Dietary prebiotics and probiotics are of particular interest for prevention and amelioration of autoimmune inflammatory diseases, due to their potential to foster healthy host-microbiome relationship. The rational dietetics aims towards balancing friendly versus enemical microbes via manipulation of gut environment and modulation of immune system to improve regulation of inflammatory and autoimmune mechanisms.

Key words:

Psoriasis, Autoimmunity, Microbiota, Dysbiosis, Endotoxins, Epigenetic, Superantigens.

*Corresponding Author:

Abhay Kumar Pandey, Department of Physiology, All India Institute of Medical Sciences, Bhopal, India. Email: abhay.physiology@gmail.com

Cite this article as:

Pandey G, Pandey AK, Pandey SS, Pandey BL. Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis. Biomed Res J. 2015;2(2):220–232.

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