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Biomedical Research Journal

Volume 2, Issue 1, April 2015, Pages 37–56

Review

Developmental signalling in maintenance and regulation of cancer stem cells

Sweta Dash, Raghava Reddy Sunkara and Sanjeev K. Waghmare*

Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India

Abstract:

Tissue stem cells self-renew throughout the life of an organism thereby maintaining tissue homeostasis and prevent cancer. The major signalling pathways such as Wnt, Notch and Sonic hedgehog control the stem cell regulation and their deregulation leads to cancer. Recent evidences showed that there exists a subset of cells within tumour termed as cancer stem cells (CSCs). These CSCs escape the conventional chemoradiotherapy and further lead to tumour relapse followed by metastasis. This review focuses on the developmental signalling pathways that are involved in the regulation and maintenance of normal stem cells and CSCs. Understanding the molecular mechanism may be useful to specifically target the CSCs while sparing the normal stem cells to reduce tumorigenecity.

Key words:

Cancer stem cells (CSCs); EMT, Epithelial to mesenchymal transition; Lineage tracing; β-catenin; NICD, Notch intracellular domain.

*Corresponding Author:

Sanjeev K. Waghmare, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India. Email: swaghmare@actrec.gov.in

Cite this article as:

Dash S, Sunkara RR, Waghmare SK. Developmental signalling in maintenance and regulation of cancer stem cells. Biomed Res J. 2015;2(1):37–56

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