connect with us
For further information please fill the details below:
Skip to main content

Biomedical Research Journal

Volume 2, Issue 1, April 2015, Pages 21–36

Review

Dendrimers based electrochemical biosensors

Saumya Nigam1, Sudeshna Chandra2 and Dhirendra Bahadur1*

1Department of Metallurgical Engineering and Material Science, Indian Institute of Technology Bombay, Powai, Mumbai, India

2Department of Chemical Sciences, School of Science, NMIMS (Deemed-to-be) University, Vile Parle (W), Mumbai, India

Abstract:

Electrochemical biosensors are portable devices that permit rapid detection and monitoring of biological, chemical and toxic substances. In the electrochemical biosensors, the bioreceptor is incorporated into the transducer surface; and when in contact with the analyte, generates measurable signals proportional to the analyte concentration. Materials with high surface area, high reactivity, and easy dispersability, are most suited for use in biosensors. Dendrimers are nanomaterial gaining importance for fabrication of electrochemical biosensors. These are synthetic macromolecules with regularly branched treelike and globular structure. The potential applications of dendrimers as biosensors are explored due to their geometric symmetrical structure, chemical stability, controlled shape and size, and varied surface functionalities, with adequate functional groups for chemical fixation. The current review provides multifaceted use of dendrimers for developing effective, rapid, and versatile electrochemical sensors for biomolecules. The redox centers in the dendrimers play an important role in the electron transfer process during immobilization of biomolecules on the electrodes. This has led to an intensive use of dendrimer based materials for fabrication of electrochemical sensors with improved analytical parameters. The review emphasizes development of new methods and applications of electrochemical biosensors based on novel nanomaterials

Key words:

Dendrimers, Biosensors, Polyamidoamine, Polypropylene imine, Bioreceptors, DNA sensor.

*Corresponding Author:

Dhirendra Bahadur, Department of Metallurgical Engineering and Material Science, Indian Institute of Technology Bombay, Powai, Mumbai, India. Email: dhirenb@iitb.ac.in

Cite this article as:

Nigam S, Chandra S, Bahadur D. Dendrimers based electrochemical biosensors. Biomed Res J. 2015;2(1):21–36

Connect With Us x