Volume 1, Issue 1, April 2014, Pages 71-85
Sunil Gangadharan 1 and Anjali A Karande 2
1 Johns Hopkins University School of Medicine, Department of Oncology, Orleans St Baltimore, USA
2 Department of Biochemistry, Indian Institute of Science, Bangalore, INDIA
Gonadotropin-releasing hormone (GnRH) is secreted from hypothalamic neurons and bind to receptors on gonadotrope cells of the pituitary gland, which then synthesize and release luteinizing hormone and follicle-stimulating hormone that regulate gonadal development. The presence of GnRH receptors and the effects of synthetic analogs of GnRH at extrapituitary sites is less clear. Several reports suggest that GnRH/analogues through cognate receptors may regulate mitogenic responses in cancer cells in an autocrine or paracrine manner. However, the inherent intracellular signaling pathways triggered are unknown. Using a highly specific antibody to human GnRH receptor we show that T47D breast cancer cells express GnRH receptors on their surface and that a GnRH analogue Cetrorelix inhibits proliferation of these cells, possibly via inhibition of processes that trigger cAMP formation.
GnRH-analogues, cancer cell proliferation, cell-signaling.
Anjali A Karande, Department of Biochemistry, Indian Institute of Science, Malleswaram, Bangalore – 560012, INDIA. Email: firstname.lastname@example.org
Gangadharan S, Karande AA. Modulation of proliferation by gonadotropin-releasing hormone receptors in breast cancer cells. Biomed Res J. 2014;1(1):71-85.