Dr. Aparna Khanna
Ph.D., MDBA, M.Sc., B. Sc.,
Areas of Specialisation
- Invited talks (National & International) : 50
- Articles published : 40
- Book Chapters : 2
- Shelat R, Sudeshna Chandra S, Khanna A. Detailed toxicity evaluation of β-cyclodextrin coated iron oxide nanoparticles for biomedical applications. International Journal of Biological Macromolecules. 2017. S0141-8130(17)33039-8. (in press). (Impact factor- 3.67).
- Mokashi P, Bhatt LK, Khanna A, Pandita N. Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia & hyperlipidemia in high fat fed and low dose streptozotacin induced type 2 diabetes mellitus rats. Biomedicine & Pharmacotherapy. 2017. S0753-3322(17)33751-4. (Impact factor- 2.75).
- Mokashi P, Khanna A, Pandita N. Flavonoids from Enicostema littorale blume enhances glucose uptake of cells in insulin resistant human liver cancer (HepG2) cell line via IRS- 1/PI3K/Akt pathway. Biomedicine and Pharmacotherapy. 2017. 90: 268-277. (Impact factor- 2.326).
- Chitrangi S, Nair P, Khanna A. 3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism. Toxicology in Vitro. 2017. 38: 8-18. (Impact factor- 2.903).
- Dutta S, Kharkar P, Sahu N, Khanna A. Molecular docking prediction and in vitro studies elucidate anti-cancer activity of phytoestrogens. Life Sciences. 2017. 185: 73-84. (Impact factor- 2.93).
- Dutta S, Khanna A. Aglycone rich extracts of phytoestrogens cause ROS-mediated DNA damage in breast carcinoma cells. Biomedicine and Pharmacotherapy. 2016. 84:1513-1523. (Impact factor- 2.326).
- Shreelekha Dutta, Aparna Khanna (2017). Aglycone rich extracts of phytoestrogens cause ROS-mediated DNA damage in breast carcinoma cells. Biomedicine and Pharmacotherapy..84:1513-24.
- Shruti Sanjay Taparia, Aparna Khanna. (2016). Procyanidin-rich extract of natural cocoa powder causes ROS-mediated caspase-3 dependent apoptosis and reduction of pro-MMP-2 in epithelial ovarian carcinoma cell lines. (2016) Biomedicine and Pharmacotherapy. 83:130-140.
- Chitrangi S, Nair P, Khanna A. (2016). Three dimensional polymer scaffolds for enhanced differentiation of human mesenchymal stem cells to hepatocyte-like cells: A comparative study. Journal of Tissue Engineering and Regenerative Medicine. (Epub. doi: 10.1002/term.2136
- Raut A, Khanna A. (2016). Enhanced expression of hepatocyte-specific microRNAs in valproic acid mediated hepatic trans-differentiation of human umbilical cord derived mesenchymal stem cells. Experimental Cell Research. 343(2): 237-247
- Sanganeria P, Chandra S, Bahadur D, Khanna A. (2015).Effect of HSA coated iron oxide labeling on human umbilical cord derived mesenchymal stem cells. Nanotechnology. 2015 Mar 27;26(12):125103
- Pluripotent embryonic like stem cells derived from corneal limbus, method of isolation and uses thereof. (2006) United States patent Application No: 20060216821
- Establishment of a human embryonic stem cell line using mammalian blastocysts (2006). United States Patent Application No: 20060286544.
- In vitro assay methods for classifying embryotoxicity of compounds (2007); WO/2008/107912
- Methods of Characterization of Mammalian Embryonic stem cells by Multiplex PCR (2009). WO/2009/087681
- A Method Of Obtaining Mesenchymal Stem Cells, Medias Method And Composition Thereof (2010). Patent filed vide patent application number 60/CHE/2010.
- 2017-2019: DBT grant - Dual modality imaging and tracking of stem cells in vivo using iron oxide nanoparticles as a tool for osteochondral repair.
- 2013-2016 : DST Grant - Synthesis and characterization of novel nanoparticles and study of their interactions with stem-cells
- 2009-2011: DBT-BCIL- (SBIRI) Grant (Avesthagen Ltd, Bangalore)-Hepatocyte-like cells generated from human embryonic stem cells (hESC) for hepatotoxicity screening of xenobiotics in the drug discovery process.
- University of Colorado Health Sciences Centre, Denver, USA; Identification and characterization of the HCV RdRp gene and its role in viral replication.
- 1999-2000: DBT Overseas Associateship (Rajiv Gandhi Centre for Biotechnology)
- 1998-2000: DST Young Scientist Award (Rajiv Gandhi Centre for Biotechnology) Cloning and expression of the RNA-dependent RNA polymerase gene (RdRp) of HCV.
- 1995-1996: Wellcome Trust Post-Doctoral Award (Institute of Virology, University of Glasgow, UK) May 95-April 96, Institute of Virology, Glasgow, UK; Characterization of Indian isolates of hepatitis C Virus (HCV) and study of envelope genes.
- 1987: Joint CSIR-UGC NET Examination
- 1987: GATE-87
Areas of Research
Dr Khanna’s doctoral work involved molecular and cellular characterization of the hepatitis C virus (HCV) and development of an immunodiagnostic assay using the capsid protein of HCV. Her post-doctoral work included the characterization of Indian isolates of HCV and mapping the immunodominant region of the HCV envelope protein using synthetic peptides.
Subsequently, Dr Khanna has been working in the area of stem cells since 2003. Her group was the first to report the establishment of a characterized human embryonic stem cell line from the Indian subcontinent in 2006.
Her current focus of research is design of novel nanoparticles for stem cell tracking, miRNA regulation and role in stem cell differentiation and scaffolds and biomaterials for tissue engineering, in the stem cell area. Dr Khanna is also involved in projects related to evaluation of hepatoprotective activity of phytoextracts, effect of phytoextracts in modulating breast carcinoma cells and ovarian cancer, using cell lines as a model system. Further, studies to ascertain the mechanism of action of the phytoextracts have been undertaken.
Current Academic Activities
Teaching: 5 Year Integrated MSc in Biomedical Science/MSc/MSc-Integrated program (Cell biology and Stem Cells)
Mentor for Ph. D. Students: 5 (Completed): 1 (Ongoing)
- Recognized Guide (M. Sc. and Ph. D.) – University of Mumbai and University of Kerala
- Thesis Examiner – University of Pune
- Life Member– Biotechnology Society of India, New Delhi (BSI)
- Life Member – Indian Society of Cell Biology (ISCB)
- Charter Member– International Society for Stem Cell Research (ISSCR)
- Reviewer for Journals – Differentiation , Stem Cells Development, Stem Cells, Drug Discovery Today, Yonsei Medical Journal, Cell Proliferation, Cell Biology International, Cytotherapy, Stem Cell Reviews and Reports, Indian Journal of Experimental Biology
- Former Associate Editor – Journal of Stem Cells, Nova Publishers
- Co-Editor-In-Chief- Biomedical Research Journal, NMIMS Sunandan Divatia School of Science